The transition of novel and potentially promising medical therapies into their initial human clinical trials can engender conflicting pressures. On the one side, because Phase I trials raise greater ethical and human protection challenges than later stage clinical trials, there is a need to proceed cautiously. This is particularly the case for Phase I trials with a novel therapy being tested in humans for the first time, usually termed first-in-human (FIH) trials, especially if the FIH trial involves significant risks. On (...) the other side, scientists interested in having their research validated, corporations with a financial interest in the field, and potential patients and patient support groups desirous of having .. (shrink)

«Existe-t-il une argumentation juridique?», c’est la question à laquelle tente de répondre l’ouvrage de Stefan Goltzberg, intitulé explicitement L’argumentation juridique. Si l’auteur commence son ouvrage en posant directement la question, on en cherche aussitôt, par un réflexe de «juriste», la définition. Et il faut probablement lire l’intégralité de ce petit ouvrage pour voir se profiler une définition de l’argumentation juridique. Or, au cours de cette lecture Stefan Goltzberg nous montre en quoi chercher la définition, la poser, est déjà une marque (...) argumentative (p. 25) et certainement une marque de l’argumentation juridique. Or, Stefan Goltzberg n’est pas juriste de formation. Philosophe et linguiste, il est, notamment membre du Centre Perelman de philosophie du droit au sein duquel il a écrit une thèse de philosophie intitulé Théorie et histoire de la philosophie du droit, philosophie du droit de Chaïm Perelman, de Theodor Viehweg, de Roscoe Pound.Le droit est d’abord un objet d’ .. (shrink)

Le roi et la reine de France font compte à part : si la séparation du roi et de la reine comme mode habituel de vie de couple princier est bien actée à la fin du Moyen Âge, qu’en était-il au xiiie siècle, c’est-à-dire au moment de l’émergence de l’hôtel réginal? Si la question des institutions et de l’entourage royaux a fait l’objet d’une attention renouvelée ces dernières années elle n’a pas vraiment concerné l’hôtel de la reine. Pourtant la naissance (...) de cet hôtel dans le royaume de France est peut-être à replacer dans un contexte bien plus politique que les historiens ne le laissaient à penser. En effet, l’étude de la personnalité de Marguerite de Provence (1221‑1295) mérite de soulever d’intéressants questionnements en lien avec cette thématique. Il s’agit également d’élaborer une réflexion sur la chronologie de l’apparition institutionnelle de l’hôtel réginal, indépendamment de celui du roi, et de montrer que Marguerite de Provence est probablement la première reine en Occident à en posséder un. (shrink)

Dans The Subjection of Women (1869), Mill fait bien plus que prôner l’égalité civique des hommes et des femmes : il entreprend une véritable révolution épistémologique pour déconstruire les représentations naturalisantes du caractère féminin. S’il compare d’abord la condition des femmes à celle des esclaves, c’est pour ensuite l’en distinguer, car la persistance de l’inégalité des sexes est en contradiction avec les principes juridiques des sociétés modernes. Il est donc attentif à la situation singulière du problème de l’assujettissement des femmes (...) : il ne s’agit pas de chercher à faire une « révolution sociale au nom d’un droit abstrait », mais de déraciner les préjugés qui expliquent la permanence archaïque de l’inégalité des sexes. C’est l’occasion d’une réflexion sur la construction de la domination patriarcale comme habitude sociale, par l’influence de l’éducation sur le caractère féminin. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Body and Soul in the Philosophy of Plotinus AUDREY N. M. RICH BEFORE THE TIME Of Aristotle, there had been no serious philosophical enquiry into the relation existing between the body and the soul. Admittedly, in those Dialogues of Plato in which the problem of Motion begins to assume importance, something approaching a scientific interest in the question starts to emerge. In the Phaedrus, for instance, the soul (...) is considered as the source of all bodily movement and change,1 and in the Timaeus, the interaction of body and soul is given some attention and a special bodily organ allotted to each phase of the tripartite soul (69c-71a). But it is fair to say that on the whole, Plato does not give the impression of being vitally concerned about the soul-body relation. In fact, in the Phaedo, he makes it abundantly clear that he views such an association as morally regrettable rather than scientifically interesting; at this stage of his thought, he prefers, like Socrates, to ignore such questions as those discussed by Empedocles and Alcmaeon, namely, "whether we think with the blood, or whether it is the brain that is the seat of sensation" (96b). Thus, to some extent Plato merits the censure of Aristotle who, in the De Anirna (I:1,407b15-18), ranks him among those who "associate the soul with and place it in the body without specifying why this is so and how the body is conditioned." In Aristotle's opinion, examination of the soul-body connection is essential: "for it is by this association that the one acts and the other is acted upon, that the one moves and the other is moved; and no such mutual relation is found in haphazard combinations" (407b 18-21). Now there is a strong likelihood that Aristotle's criticism of Plato on this point may have led Plotinus to take up the problem to some extent neglected by his master. He must have known the De Anima, probably through the commentaries of Alexander of Aphrodisias which, we know, were read in his school along with the writings of other Peripatetics like Aspasius and Adrastus2; and although he did not himself envisage the soul-body relation in Aristotelian terms, nevertheless his whole enquiry into the subject is deeply colored by the language and influence of the De Anirna. Of course, Plotinus is much too loyal a Platonist to remain untouched by the dualism of the t245c-e; cp. Laws X: 898c5. ~Porphyry, Life of Plotinus, c. 15. [q 2 HISTORY OF PHILOSOPHY Phaedo, and the undertone of suspicion and hostility toward the body which is lacking in the De Anima but present in much of Plato, runs right through the Enneads of Plotinus. In fact, almost the last words of his final treatise on psychology reveal that this uneasy attitude persists to the end: "Life in the body," he says, "is in itself evil.''~ Strictly speaking, however, the extreme dualism of a Dialogue like the Phaedo has no real place in Plotinus' system. In his view, both body and soul are alike descended from the primal Absolute or One; each represents a different stage in the evolution of plurality from unity; soul is an earlier stage, body, a later; and though soul does not require body in order to exist, nevertheless, without body, it could never come forth fTom the intelligible realm to display its powers in the visible universe (IV: 3.9). Thus, because body is, in a sense, necessary to soul, because, figuratively speaking, it is the only "place" appropriate for the soul's occupation (IV: 3.9), it is impossible to view the relation between body and soul as one of unmitigated hostility. For to some extent, body and soul imply each other. On the cosmic level indeed, they never exist apart. For though we may speak of the "ensoulment" (~Ft~c0oLg) of the cosmos, because the cosmos is, in fact, eternal and uncreated, there never was a time when its soul and its body were dissociated (IV : 3.9). In the case of the human soul and body, however, matters are rather different, since it is evident that the two were separate... (shrink)

La fouille du puits 883, menée par la mission française de Kition à Bamboula (2017-2018), a livré de nombreux restes fauniques au sein d’un comblement daté du ive siècle apr. J.‑C. Cet article présente les résultats d’une étude collaborative réalisée par des archéozoologues qui ont mis en évidence une grande diversité animale (bétail, carnivores, coquillages, oiseaux, rongeurs, reptiles, poissons). Ce matériel faunique offre l’opportunité d’aborder le paysage animalier d’un secteur de la ville antique dans sa multiplicité, avec des animaux liés (...) directement aux pratiques économiques et domestiques (élevage, consommation carnée, utilisation d’animaux auxiliaires) dont les déchets s’avèrent de différentes natures (alimentaires, équarrissage, cadavres animaux). D’autres espèces, plus discrètes, ont su profiter des déchets et denrées produites par les habitants de ce quartier, témoignant ainsi de la porosité entre contextes urbanisés et environnements naturels. (shrink)

L’article discute les conceptions respectives que le philosophe Ernst Cassirer et l’historien de l’art Erwin Panofsky se font de l’espace artistique. L’occasion en est donnée par une discussion lors du Kongress für Ästhetitk und Allgemeine Kunstwissenschaft (Congrès d’esthétique et de science de l’art) organisé à Hambourg en 1933 sur la question de l’espace et du temps artistiques. La perspective, considérée par Panofsky comme une forme symbolique, constitue un bon cas pour saisir les proximités et différences entre l’historien de l’art et (...) le philosophe des formes symboliques. L’espace de la perspective correspond-il à cet espace de l’art que le philosophe définit comme espace de la représentation (Darstellung)? À cet exemple de la perspective, exemple classique quoique souvent évoqué sans grande précision pour comparer les deux théoriciens, l’article en ajoute un autre, inédit, à savoir celui de la théorie des proportions. Peut-on dire que la théorie des proportions qui structure elle aussi la surface de l’image est, comme la perspective, une forme symbolique? La réponse permet de préciser la façon dont Cassirer et Panofsky construisent un lien entre art, représentation et subjectivité. À travers cette recherche des affinités et différences dans la conception de l’art, ce qui se joue en toile de fond, c’est, d’une part, la possibilité et les limites de l’interdisciplinarité et du dialogue fécond entre philosophie et histoire de l’art et, d’autre part, la question de savoir si une commune théorie de l’art était partagée à Hambourg dans ces années, autour de l’Institut Warburg. (shrink)

There are many good reasons to learn about the lives of people who have less social privilege than we do. We might want to understand their circumstances in order to have informed opinions on social policy, or to make our institutions more inclusive. We might also want to cultivate empathy for its own sake. Much of this knowledge is gained through social scientific or humanistic research into others' lives. The entitlement to theorize about or study the lives of marginalized others (...) is often granted under the presumption of academic freedom. This paper will not question whether academic freedom licenses us to do so in the first place ; instead, I will... (shrink)

Though the details about Gregory of Elvira’s personal life and much of his ecclesial work are sparse, we do possess information concerning his pastoral concerns and his position in the Christological disputes of his era. These insights come from his own writings as well as the comments offered to him and about him from his contemporaries. His writings demonstrate a rather wide-ranging familiarity with western theologians such as Tertullian, Novatian, Lactantius, and Hilary, but Gregory was not simply a copyist. He (...) was willing to utilize and then expand upon his sources as he saw fit, and this is especially visible in his Christological materials. This article will examine these influences on Gregory, especially regarding his promotion of the Nicene creed, both from his setting in Roman Spain and from the literary and theological sources he drew upon. These demonstrate that Gregory supported the theology of the Nicene creed even as he learned to refine his own language and expand his defense of the creed and its key term homousios. (shrink)

Open Access: This paper will connect literature on epistemic injustice with literature on victims and perpetrators, to argue that in addition to considering the credibility deficit suffered by many victims, we should also consider the credibility excess accorded to many perpetrators. Epistemic injustice, as discussed by Miranda Fricker, considers ways in which someone might be wronged in their capacity as a knower. Testimonial injustice occurs when there is a credibility deficit as a result of identity-prejudicial stereotypes. However, criticisms of Fricker (...) have pointed out that credibility is part of a more complex system that includes both deficits and excesses. I will use these points to argue that we should look closer at sources of credibility excess in cases of sexual assault. This means that in addition to considering sources of victim blaming by looking at ways in which “ideal” victims are constructed, we also need to consider ways in which “ideal” perpetrators are constructed. (shrink)

Erratum to: Int J Semiot Law DOI 10.1007/s11196-014-9376-7Dans la publication originale de cet article, l’auteur n’a pas cité le titre correct de la thèse de philosophie de Stefan Goltzberg.A la dernière phrase du premier paragraphe, il ne faut pas lire «il a écrit une thèse de philosophie intitulé Théorie et histoire de la philosophie du droit, philosophie du droit de Chaïm Perelman, de Theodor Viehweg, de Roscoe Pound» mais bien «il a écrit une thèse de philosophie intitulée Théorie bidimensionnelle de (...) l’argumentation. Définition, Présomption, Argument A fortiori». (shrink)

The study's purpose was to estimate the variety of foods consumed within standard and ethnic food categories by three groups of women between 18 and 35 years of age. Foreign-born Chinese women [N = 21], Chinese-American women [N = 20] and white American women [N = 23] kept 4-day food records, after instruction. Analysis of variance showed that the mean number of different foods consumed by the foreign-born Chinese was significantly [p < 0.05] lower than those eaten by the other (...) two groups for breads/cereals, dairy products, ethnic foods, fats, meats, sweets/sugars, and vegetable categories. White American women consumed significantly more dairy products and legumes/nuts than either of the groups of Chinese women. Diets of the Chinese-American women were more nutrient dense than those of the women in the other groups, containing significantly more energy, riboflavin, iron, folacin, and calcium than those of the foreign-born Chinese women. The percentage of kilocalories derived from fat [33–34%] did not differ among groups. 95% of foreign-born and 85% of Chinese-American women affirmed their ethnic identification by consuming foods belonging to Chinese cuisine; whereas, the percentage [30%] of white American women selecting Chinese food was significantly lower. Mexican and Italian foods were selected by significantly more white and Chinese-American women than by foreign-born Chinese women. Approximately 20% of both groups of Chinese women, but 49% of white American subjects, ate Japanese food. Chinese-American women retained a preference for Chinese food, similar to that of the foreign-born Chinese women. However, the Chinese-American women consumed cheeses, legumes, raw vegetables in salads, and foods from Italian and Mexican cuisines, indicating their acceptance of foods commonly consumed by white American women. Dietary acculturation among the Chinese-American women improved their diets over those of the foreign-born Chinese women and these results support the theory that consumption of a greater variety of foods increases nutrient density of diets. (shrink)

Criticism can sometimes provoke defensive reactions, particularly when it implicates identities people hold dear. For instance, feminists told they are upholding rape culture might become angry or upset, since the criticism conflicts with an identity that is important to them. These kinds of defensive reactions are a primary focus of this paper. What is it to be defensive in this way, and why do some kinds of criticism, or implied criticism, tend to provoke this kind of response? What are the (...) connections between defensiveness, identity, and active ignorance? What are the social, political, and epistemic consequences of the tendency to defensiveness? Are there ways to improve the situation? (shrink)

Keisha Ray and Jane Falls Cooper’s article “Bioethics of Environmental Injustice: Ethical, Legal, and Clinical Implications of Unhealthy Environments” seeks to give environmental concerns greater p...

We conjecture that corporate social responsibility can be indicative of managerial ethics and integrity and examine whether equity investors and financial analysts consider CSR performance when they assess firms’ disclosures of actual and forecasted earnings. We find that only adverse CSR performance affects investors’ assessments of these disclosures. In contrast, we find that both positive and adverse CSR performance affect analysts’ forecast revisions in response to firms’ disclosures. We also find that firms with adverse CSR performance exhibit lower disclosure quality (...) and earnings persistence, but do not find that firms with positive CSR performance exhibit higher levels of both measures. This asymmetric result is consistent with investors’, but not analysts’, assessments of the effect of CSR performance on corporate disclosures. Our results are robust to using a three-stage least squares approach to address endogeneity concerns and to a battery of robustness and sensitivity analyses. Overall, our findings suggest that investors and analysts consider CSR when assessing the information in earnings-related corporate disclosures. (shrink)

The purpose of this qualitative study was to examine the perceptions related to ethics and cheating among a representative sample of primarily female undergraduate students, compared to trends reported in the literature. Focus groups were organized to discuss nine scripted questions. Transcripts and audiotapes were analyzed and four main themes emerged: demographics of those who cheat, students’ perceptions of cheating, the role of technology in cheating, and consequences of cheating, including students’ attitudes and behaviors related to reporting cheating incidents. Bandura’s (...) Social Cognitive Theory served as the theoretical framework to understand students’ varying perceptions of and justification for cheating, as well as the dynamics of honor code violations, via group discussion. Viewpoints on cheating were regularly discussed and contradictory views were identified related to frequency and justification for cheating. Utilizing the constant comparative method, students mentioned time limitations, and pressure from peers, parents, and professors as reasons to cheat. They also discussed pressures to achieve high grades for acceptance into graduate programs. Students were also reluctant to report their classmates for cheating incidents. Repeated and comprehensive education on ethical behavior is warranted. (shrink)

Faculty workload inequities have important consequences for faculty diversity and inclusion. On average, women faculty spend more time engaging in service, teaching, and mentoring, while men, on average, spend more time on research, with women of color facing particularly high workload burdens. We explore how faculty members perceive workload in their departments, identifying mechanisms that can help shape their perceptions of greater equity and fairness. White women perceive that their departments have less equitable workloads and are less committed to workload (...) equity than white men. Women of color perceive that their departments are less likely to credit their important work through departmental rewards systems than white men. Workload transparency and clarity, and consistent approaches to assigning classes, advising, and service, can reduce women’s perceptions of inequitable and unfair workloads. Our research suggests that departments can identify and put in place a number of key practices around workload that will improve gendered and racialized perceptions of workload. (shrink)

Despite significant promotion of diversity in companies, as well as legislation for equal opportunities for women and men, it must be noted that women still remain largely in the minority in decision-making positions. This observation reflects the phenomenon of the glass ceiling that constitutes vertical discrimination within companies against women. Although the glass ceiling has generated research interest, some authors have pointed out that theoretical models have made little attempt to develop an understanding of this phenomenon and its implications. Therefore, (...) our study aims to fill this gap and to better understand the phenomenon of the glass ceiling by considering both its antecedents and its possible consequences. More precisely, we extend the model developed by Elacqua et al., proposing a more comprehensive model including organizational gender culture as a third factor in the emergence of the glass ceiling through the perception of differential treatment. We also investigated the glass ceiling’s consequences for organizational attitudes and well-being at work by considering work-to-family conflict as a possible mediator. We surveyed 320 women in managerial positions in a Belgian organization. Our study highlights the importance of all three factors in the emergence of the perception of differential treatment and, ultimately, the perception that a glass ceiling exists. Moreover, our results show that WFC fully mediates the effects of the glass ceiling on job strain and job engagement, and partially mediates the effects of the glass ceiling on job satisfaction and intention to quit. (shrink)

Feminist epistemologies consider ways in which gender influences knowledge. In this article, I want to consider a particular kind of feminist empiricism that has been called feminist radical empiricism. I am particularly interested in this view's treatment of values as empirical, and consequently up for revision on the basis of empirical evidence. Proponents of this view cite the fact that it allows us to talk about certain things such as racial and gender equality as objective facts: not just whether we (...) have achieved said equality in our society, but whether we are, in fact, all equal. I will raise the concern that the way in which they model the role of values in epistemology may be a problematic idealization of the open-mindedness of human agents. In some cases, resistance to value-change cannot be diagnosed as a failure to respond adequately to evidence. If so, the strategy of empirically testing our values that some feminist radical empiricists suggest may not be as useful a tool for social change as they think. (shrink)

Nous proposons quelques remarques concernant la philosophie et son enseignement, en nous appuyant sur une conférence prononcée en 1975 par le philosophe tchèque Jan Patočka intitulée « L’homme spirituel et l’intellectuel », et dans laquelle Patočka décrit le genre de vie propre au philosophe par opposition à celui qu’il nomme « l’intellectuel » reprenant par là, et lui donnant toutefois un souffle nouveau, l’opposition platonicienne entre le philosophe et le sophiste. Nous approfondissons cette lecture par l’analyse d’un essai antérieur datant (...) de 1934, extrait du volume Liberté et sacrifice et intitulé « Remarques sur la position de la philosophie dans et en dehors du monde ». Nous souhaiterions montrer que dans ces deux textes, Patočka expose, partant de la figure de Socrate, le genre de vie du philosophe, faisant ainsi apparaître une figure de l’enseignement moins grecque que johannique. (shrink)

This article, based on a socio-cognitive approach, deals with the professional training of student teachers in French agricultural education during their practical work experience. The main objective is to demonstrate that the student teacher’s social interaction with his academic advisor allows him to use and develop his professional knowledge relating to practical matters. Based on a qualitative analysis this study presents the results of an investigation of seven students and six academic advisors. The article studies the interrelations between the nature (...) of the professional knowledges in question and the processes of construction in the work. (shrink)

The logical empiricists often appear as a foil for feminist theories. Their emphasis on the individualistic nature of knowledge and on the value-neutrality of science seems directly opposed to most feminist concerns. However, several recent works have highlighted aspects of Carnap's views that make him seem like much less of a straightforwardly positivist thinker. Certain of these aspects lend themselves to feminist concerns much more than the stereotypical picture would imply.

An ad hominem fallacy is committed when an individual employs an irrelevant personal attack against an opponent instead of addressing that opponent’s argument. Many discussions of such fallacies discuss judgments of relevance about such personal attacks, and consider how we might distinguish those that are relevant from those that are not. This paper will argue that the literature on bias and testimony can helpfully contribute to that analysis. This will highlight ways in which biases, particularly unconscious biases, can make ad (...) hominem fallacies seem effective, even when the irrelevance is recognized. (shrink)

This book is a practical guide for K-12 educators as well as parents of students who are identified as being in the top academic percentiles of the population.

Many criticisms of epistemic logic have centered around its use of devices such as idealized knowers with logical omniscience and perfect self-knowledge. One possible response to such criticisms is to say that these idealizations are normative devices, and that epistemic logic tells us how agents ought to behave. This paper will take a different approach, treating epistemic logic as descriptive, and drawing the analogy between its formal models and idealized scientific models on that basis. Treating it as descriptive matches the (...) way in which some philosophers, including one of its founders, Jaako Hintikka, have thought about epistemic logic early in its history. Further, the analogy between the two fields will give us a way to defuse criticisms that see epistemic logic as unrealistic. For example, criticizing models of epistemic logic in which agents know all propositional tautologies as being unrealistic would be like criticizing frictionless planes in physics for being unrealistic. Each one would certainly be an unsuitable model for studying some kinds of phenomena, but is entirely appropriate for others. After outlining the analogy between epistemic and scientific models, we will discuss some ways in which idealizations are used by different research programs in epistemic logic. (shrink)

Games may seem like a waste of time, where we struggle under artificial rules for arbitrary goals. The author suggests that the rules and goals of games are not arbitrary at all. They are a way of specifying particular modes of agency. This is what make games a distinctive art form. Game designers designate goals and abilities for the player; they shape the agential skeleton which the player will inhabit during the game. Game designers work in the medium of agency. (...) Game-playing, then, illuminates a distinctive human capacity. We can take on ends temporarily for the sake of the experience of pursuing them. Game play shows that our agency is significantly more modular and more fluid than we might have thought. It also demonstrates our capacity to take on an inverted motivational structure. Sometimes we can take on an end for the sake of the activity of pursuing that end. (shrink)

This book redresses the balance by examining theory, research, policy, and practice in both fields.